Format
Scientific article
Publication Date
Published by / Citation
Li Liu, Sarah E Wheeler, Raman Venkataramanan, Jacqueline A Rymer, Anthony F Pizon, Michael J Lynch, Kenichi Tamama; Newly Emerging Drugs of Abuse and Their Detection Methods: An ACLPS Critical Review, American Journal of Clinical Pathology, Volume 149, Issue 2, 29 January 2018, Pages 105–116, https://doi.org/10.1093/ajcp/aqx138
Original Language

English

Country
United States
Keywords
clinical chemistry
gas chromatography-mass spectrometry
designer drugs
toxicology
Substance abuse detection

Newly Emerging Drugs of Abuse and their Detection Methods

Abstract

Objectives: Illicit drug abuse has reached an epidemic level in the United States. Drug overdose has become the leading cause of injury-related deaths since 2008 due to the recent surge of opioid overdose by heroin, controlled prescription drugs, and nonmethadone synthetic opioids. Synthetic designer drugs such as synthetic cathinones (“bath salts”) and synthetic cannabinoids (“Spice” and “K2”) continue to emerge and attract recreational users.

Methods: The emergence of new drugs of abuse poses a steep challenge for clinical toxicology laboratories. Limited information about the emerging drugs and their metabolism, “rebranding” of the illicit drugs, and a lack of Food and Drug Administration-approved screening methods for these drugs contribute to this difficulty. Here we review detection methods that can aid in identifying emerging drugs of abuse

Results: One promising approach is the utilization of untargeted drug screening by mass spectrometry. Historically, gas chromatography-mass spectrometry has been the gold standard.

Conclusions: Liquid chromatography-tandem mass spectrometry and liquid chromatography-high-resolution mass spectrometry offer improved detection capability of new drugs with simplified sample preparation, making it the new standard.

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