Format
Scientific article
Publication Date
Published by / Citation
Louisa Degenhardt, Brodie Clark, Georgina Macpherson, Oscar Leppan, Suzanne Nielsen, Emma Zahra, Briony Larance, Jo Kimber, Daniel Martino-Burke, Matthew Hickman, Michael Farrell, Buprenorphine versus methadone for the treatment of opioid dependence: a systematic review and meta-analysis of randomised and observational studies, The Lancet Psychiatry, 2023
Keywords
buprenorphine
Methadone
Opioid Use Disorder

Buprenorphine versus methadone for the treatment of opioid dependence: a systematic review and meta-analysis of randomised and observational studies

Opioid dependence is associated with substantial health and social burdens, and opioid agonist treatment (OAT) is highly effective in improving multiple outcomes for people who receive this treatment. Methadone and buprenorphine are common medications provided as OAT. We aimed to examine buprenorphine compared with methadone in the treatment of opioid dependence across a wide range of primary and secondary outcomes.