Genetics

Illicit Drug Use and the Genetic Overlap with Cannabis Use

Scientific article
Abstract Background The use of illicit substances is correlated, meaning that individuals who use one illicit substance are more likely to also use another illicit substance. This association could (partly) be explained by overlapping...

Illicit Drug Use and the Genetic Overlap with Cannabis Use

Scientific article
Abstract Background Poor sleep quality and insomnia have been associated with the use of tobacco, alcohol, and cannabis, but it is unclear if there is a causal link. In this Mendelian Randomization (MR) study we examine if insomnia causes...

ADGRL3 (LPHN3) Variants Predict Substance Use Disorder

Scientific article
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Abstract Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder...

Gene Therapy for Cocaine Addiction

Scientific article
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Cocaine addiction is linked with uncontrollable drug seeking. Cues within the environment act as a constant reminder of the experience and can lead to relapse. Current medication options are limited when it comes to meeting the needs for...

How Cocaine Cues Get Planted in the Brain

Scientific article
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Individuals suffering from substance use disorders develop strong associations between the drug’s stimulating effect and environmental cues that act as reminders of the experience, which can lead to relapse. A recent study has proposed a...

Genetic Etiology for Alcohol-Induced Cardiac Toxicity

Scientific article
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Abstract Background: Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left ventricle due to chronic excess alcohol consumption. It is largely unknown which factors determine cardiac toxicity on exposure to alcohol...