Jose Luis Vazquez Martinez An opponent process for alcohol addiction based on changes in endocrine gland mass Jose Luis Vazquez Martinez - 9 March 2021 Source: Karin, O., Raz, M., & Alon, U. (2021). An opponent process for alcohol addiction based on changes in endocrine gland mass. Iscience, 102127. Highlights •Addiction involves tolerance and withdrawal over weeks •Model of the HPA-axis and β-endorphins explains tolerance and withdrawal •Effects due to changes in the functional mass of endocrine glands •Fold-change detection makes circuit prone to addiction but boosts learning An opponent process for alcohol addiction based on changes in endocrine gland mass.pdf