Cannabis Use and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

Source:

Catapano, J. S., Rumalla, K., Srinivasan, V. M., Labib, M. A., Nguyen, C. L., Rutledge, C., ... & Lawton, M. T. (2022). Cannabis Use and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Stroke, STROKEAHA-121.

Growing evidence links cannabis use to cerebrovascular disease, including aneurysmal subarachnoid hemorrhage (aSAH)1 and acute ischemic stroke.2 In a population-based study, the aSAH incidence was twice as high in cannabis users as in nonusers in a younger age group.3 The pathophysiology of this association is unknown, but research suggests that multifocal intracranial stenosis, oxidative stress, and cerebral mitochondrial dysfunction are contributors. Given the popularization of cannabis use in the United States, it is essential to continue evaluating the associated risks and benefits. This study investigates the effects of cannabis on delayed cerebral ischemia (DCI) and other outcomes of patients with aSAH.